Ratlara Malathion ve Rutin Uygulamalar? Sonras? Akci?er Dokular?nda Metalloproteinaz Düzeyleri ile Oksidatif Stres ve Apoptoz Belirteçlerinin De?erlendirilmesi

Malathion (MLT) is an important environmental pollutant in the organophosphate class. Rutin (RUT), on other hand, one of flavonoid family members whose effectiveness against various toxic agents has been extensively studied. In present study, effects MLT and RUT treatments oxidative stress, apoptosis metalloproteinases lung tissues rats were investigated. MDA, GSH, Nrf2, HO-1, MMP2, MMP9 caspase-3 levels analyzed by biochemical or RT-PCR method after received and/or treatment for 28 days. The data showed that MLT-induced MDA decreased treatment. addition, it was determined Nrf2 HO-1 mRNA transcript GSH suppressed approached control group up-regulated expression (MMP2 MMP9) tissues, while down-regulated these genes. observed triggered expression, exerted anti-apoptotic effect suppressing caspase-3. As a result, through metalloproteinases, could alleviate effects.